A lane of northbound Highway 63 is scheduled to be closed over I-70 in Columbia.
MoDot says crews need to fix a bridge joint.
The one-lane traffic on northbound 63 was set to start at 6 p.m. Sunday. The work is supposed to continue around-the-clock until Wednesday.
Monday, Highway 179 is closing just south of I-70 near Wooldridge at the Petite Saline Creek bridge. Crews are replacing the bridge.
MoDot says Route 179 will be closed for up to five months.